Firefighters were called to a car alight on the M4 near Junction 3.
A car overturned and was destroyed by fire. Firefighters rescued two people from the vehicle. Sadly, a man was pronounced dead at the scene. Three further people were taken to hospital by London Ambulance Service crews.
The road is currently closed in both directions whilst firefighters work with partners to make the scene safe.
The Brigade was called at 1137 and the incident was over for firefighters by 1322. Three fire engines and a command unit from Heathrow, Feltham, Heston and Hayes fire stations attended the scene.