Four fire engines and around 25 firefighters tackled a fire at a waste recycling plant on Devon Street in Southwark.
Around 20 tonnes of mixed recycling waste were destroyed by fire. There are no reports of any injuries.
The Brigade was called at 0214 and the fire was under control by 0508. Crews from Old Kent Road, New Cross, Peckham and Dockhead fire stations attended the scene.
The cause of the fire is under investigation.