Four fire engines and around 25 firefighters were called to a fire at a house on Atkinson Road in West Beckton.
Part of the first floor and second floor of a three-storey house was damaged by the blaze.
A man left the property before the Brigade arrived. He was taken to hospital by London Ambulance Service crews.
The Brigade was called at 2256 and the fire was under control at 0026. Fire crews from Plaistow, East Ham, Stratford and Barking fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.