Fifteen fire engines and around 80 firefighters dealt with a severe fire in a bakery and restaurant on Minerva Road in Park Royal.
The majority of the two storey building was damaged by fire. Initial 999 callers reported that residential properties were involved but that was not the case.
Assistant Commissioner Graham Ellis said: “This was a severe, complex and highly visible fire with our 999 Control taking over 50 calls in the early stages. There was a lot of thick black smoke in the area and we asked local residents to close their doors and windows.
"The layout of the building and a ruptured gas main made firefighting difficult but firefighters worked throughout the night to bring it under control. Thankfully there were no reports of any injuries."
The Brigade was called at 1819 and the fire was under control by 0341. Fire crews from Acton and surrounding fire stations were at the scene.
Firefighters were on scene damping down small pockets of fire throughout the day.
The cause of the fire has been recorded as undetermined.