Fifteen fire engines and around 100 firefighters were called to a fire on Sunbeam Road in Park Royal.
Most of a single-storey industrial laundry unit and part of the roof were damaged by the fire. There were no reports of any injuries.
The Brigade's 999 Control Officers took 13 calls to the blaze.
The Brigade was called at 0219 and the fire was under control by 0532. Fire crews from Park Royal, Acton, North Kensington, Ealing, Chiswick, Wembley and surrounding fire stations were at the scene.
The cause of the fire is under investigation.