Ten fire engines and around 70 firefighters were called to a fire at a range of four industrial units on Eastbury Road in Beckton.
Two fast food takeaway units were destroyed by the blaze. A cash and carry unit and a car repair workshop were damaged. There were no reports of any injuries.
The Brigade was called at 2349 and the fire was under control by 0312 (Saturday). Fire crews from East Ham, Plaistow, Barking, Poplar, Stratford, East Greenwich and surrounding fire stations were at the scene.
The cause of the fire is under investigation.