Four fire engines and around 25 firefighters were called to a fire at a shop with flats above on Leeland Road in Ealing.
A one-roomed flat on the first floor was destroyed by fire. Firefighters wearing breathing apparatus rescued one man via an internal staircase. He was taken to hospital suffering smoke inhalation by London Ambulance Service crews, where he sadly later died. Another man left the premises before the Brigade arrived. He was also taken to hospital suffering smoke inhalation.
The Brigade was called at 2244 and the fire was under control by 2358. Fire crews from Ealing, Acton and Southall fire stations attended the scene.
The cause of the fire is under investigation.