Twelve fire engines and around 80 firefighters were called to a fire at a warehouse on Argall Avenue in Leyton.
The first floor of the two-storey warehouse was destroyed by the blaze and most of the roof was also damaged by fire. Firefighters cooled 10 gas cylinders to an ambient temperature as some cylinders can explode when exposed to heat. There were no reports of any injuries.
Station Commander Karl Smith was at the scene, he said: "On arrival crews faced a well developed fire with the ground, first and roof of the warehouse alight. They worked hard in hot conditions and made steady progress in bringing the blaze under control."
The Brigade was called at 0127 and the fire was under control by 0456. Fire crews from Leyton, Homerton, Walthamstow, Stoke Newington, Bethnal Green, Hornsey, Leytonstone and Tottenham fire stations were at the scene.
The cause of the fire is under investigation.