Fifteen fire engines and around 100 firefighters were called to a fire at a house on Vicarage Gate in Kensington.
Half of the basement and half of the ground, first and third floors of the building were damaged by fire. The roof and the fourth floor were destroyed by the blaze. Part of the second floor was also damaged. There were no reports of any injuries.
Station Commander Jon Singleton, who was at the scene, said: "On arrival, crews were faced with smoke coming from the house and upon investigation located the fire inside a wall void.
"Due to the complex location of the fire, crews used specialist cutting equipment to gain access. Crews worked throughout the night to damp down remaining hot spots and prevent the fire from spreading to adjacent properties.
"A turntable ladder was used to provide a bird's eye view and monitor the incident.
"Roads in the local area were closed whilst firefighters worked to make the scene safe."
The Brigade was called at 1254 and the fire was under control by 2133. Fire crews from Kensington, Hammersmith, North Kensington, Paddington and surrounding fire stations were at the scene.
The cause of the fire is under investigation.