Ten fire engines and around 70 firefighters were called to a fire at a scrapyard on Thames Road in Newham.
Two shipping containers were destroyed by the fire and a pile of around 150 tonnes of scrap metal was also damaged. There were no reports of any injuries.
The Brigade's 999 Control Officers took 33 calls to the blaze.
The Brigade was called at 2246 and the fire was under control by 0730 on Thursday. Fire crews from Plaistow, East Ham, Poplar, Stratford, Barking and surrounding fire stations were at the scene.
The cause of the fire is under investigation.