Six fire engines and around 40 firefighters were called to a single storey warehouse fire on Lombard Wall in Charlton.
Two lorries were gutted by fire. A further lorry and four loading bays were also damaged by the blaze. Around 120 staff evacuated the building before the Brigade arrived.
The Brigade was called at 1839 and the fire was under control by 2035. Fire crews from East Greenwich, Greenwich, Deptford, Plumstead and Poplar fire stations were at the scene. The cause of the fire is under investigation.