Four fire engines and around 25 firefighters were called to a fire at a house in Rixsen Road, Manor Park.
Part of a single storey extension was damaged by fire, as well as part of a single storey extension of a neighbouring property. A woman and three children left the property before the Brigade arrived.
The Brigade was called at 1435 and the fire was under control by 1523.
Fire crews from East Ham, Stratford, Plaistow and Ilford stations attended the incident.
The cause of the fire is under investigation.