Four fire engines and around 25 firefighters were called to a house fire on Felbrigge Road in Seven Kings.
Most of the first floor of a terraced house was damaged by fire and the loft was destroyed by the blaze. Two people left the building before the Brigade arrived. There were no reports of any injuries.
One of the Brigade's 32-metre turntable ladders was used at the scene as an observation tower, providing crews with an aerial view of the incident.
The Brigade's 999 Control Officers took 13 calls to the blaze.
The Brigade was called at 1207 and the fire was under control by 1440. Fire crews from Dagenham, Barking and Hainault fire stations attended the scene.
The cause of the fire is under investigation.