Four fire engines and around 25 firefighters were called to a house fire on Becket Close in South Norwood.
Firefighters tackled a blaze at a terraced house where part of the first floor was destroyed by the fire. Three women left the property before the Brigade arrived, all were treated at the scene by London Ambulance Service crews.
The Brigade was called at 0018 and the fire was under control by 0104. Fire crews from Woodside, Beckenham, West Norwood and Croydon fire stations attended the scene.
The cause of the fire will be investigated.