Twelve fire engines and around 80 firefighters were called to a flat fire on Eaton Place in Westminster.
Firefighters tackled a fire at a five storey residential town house, where all of the roof, part of a flat on the third and part of a flat on the fourth floor were destroyed by the fire.
The Brigade's Control Office received 26 calls about the fire.
Fire crews will remain at the scene to dampen down the area.
The Brigade was called at 1141 and the fire was under control at 1437. Fire crews from Clapham, Dowgate, Soho, Hammersmith and other surrounding fire stations attended the scene.
The cause of the fire will be investigated.