Four fire engines and around 25 firefighters tackled a house fire on Mortlake Road in Ilford.
The whole of the ground floor of a terraced house was destroyed by fire and half of the first floor was also damaged by the blaze. Two children were led to safety before the Brigade arrived. Another man and a teenager also left the building before the Brigade arrived. They were taken to hospital by London Ambulance Service crews.
The Brigade was called at 0849 and the fire was under control by 1017. Fire crews from Ilford, Barking and Dagenham fire stations attended the scene.
The cause of the fire is under investigation.