Six fire engines and around 40 firefighters tackled a fire in a maisonette in Hooper Road, Canning Town.
A four-roomed maisonette on the second and third floor was damaged by fire. A man left the property before crews arrived.
The Brigade was called at 1105 and the fire was under control by 1312. Crews from East Ham, Stratford, Barking, Leyton and surrounding stations were at the scene.
The cause of the fire is under investigation by the Metropolitan Police.