Ten fire engines and around 70 firefighter were called to a fire at a shop on the High Street in Acton.
Firefighters tackled a fire at a two-storey building where a ground floor shop and the floor above, containing flats, were completely destroyed. No injuries were reported.
The Brigade was called at 1832 and the fire was under control by 0004. Fire crews from Acton, Ealing, Hammersmith, Royal Park and other surrounding fire stations attended the scene.
The cause of the fire will be investigated.