Twenty fire engines and around 125 firefighters were called to a fire involving grassland and buildings on Ray Lamb Way in Erith.
Two commercial warehouses were destroyed by the fire and a further warehouse was damaged. An area of grassland and bushes of around five hectares was also involved in the blaze. Firefighters rescued 15 people using fire escape hoods and another 13 people were led to safety by crews. There were no reports of any injuries.
The Brigade's 999 Control Officers took 22 calls to the fire.
The Brigade was called at 1833 and the fire was under control by 0127. Fire crews from Sutton, Addington, Bexley, Sidcup and surrounding fire stations were at the scene.
The cause of the fire is under investigation.