Ten fire engines and around 70 firefighters were called to a fire at a storage unit on Pield Heath Road in Uxbridge.
A single-storey storage unit and two shipping containers were destroyed by the blaze and part of another single-storey storage unit was damaged. There were no reports of any injuries.
Station Commander Clive Robinson, who was at the scene, said: "Crews worked hard to bring the fire under control and stop it spreading to other units.
"There were a number of cylinders involved in the fire, so firefighters cooled and removed them as cylinders can explode when exposed to heat.
"There was a lot of smoke, so we advised nearby residents to keep their doors and windows closed."
The Brigade's 999 Control Officers took 18 calls to the blaze.
The Brigade was called at 1913 and the fire was under control by 2352. Fire crews from Hillingdon, Hayes, Heathrow, Southall, Ruislip, Harrow and surrounding fire stations were at the scene.
The cause of the fire is under investigation.