Four fire engines and around 25 firefighters were called to a fire at a shop with flats above in Portpool Lane in Holborn.
Part of a bedroom in a second floor flat was destroyed by fire.
The Brigade was called at 1022 and the fire was under control by 1108. Fire crews from Shoreditch, Islington, Dowgate and Whitechapel fire stations were in attendance.
The cause of the fire is under investigation.