Four fire engines and around 25 firefighters tackled a fire at a hotel on Western Gateway in Canning Town.
Part of an office on the first floor of the hotel was damaged by fire. Around 100 people left the building before the Brigade arrived and crews carried out a systematic search of the property. There were no reports of any injuries.
The Brigade was called at 0409 and the fire was under control by 0535. Fire crews from Poplar, Millwall, Stratford, East Ham and Shadwell fire stations attended the scene.
The cause of the fire is under investigation.