Four fire engines and around 25 firefighters were called to a flat fire on Chudleigh Street in Stepney Green.
Part of a split-level flat on the seventh and eighth floor of a residential block was damaged by fire. Crews wearing breathing apparatus carried out searches of adjoining flats to check for fire spread. Two adults and three children left the building before the Brigade arrived. There were no reports of any injuries.
The Brigade was called at 2244 and the fire was under control by 2259. Fire crews from Shadwell, Whitechapel, Poplar and Millwall fire stations attended the scene.
The cause of the fire is under investigation.