Six fire engines and around 40 firefighters were called to a house fire on Evelyn Denington Road in Beckton.
Part of the first floor and most of the roof of a semi-detached house were damaged by the fire. There were no reports of any injuries.
A London Fire Brigade spokesperson said: "Firefighters worked to stop the fire spreading to adjoining properties and carried out a systematic search of the neighbouring houses.
"There were a lot of possessions and clutter inside the house which made it challenging for firefighters.
"Hoarding means exit routes can become blocked, making self-evacuation more difficult. Fires can also spread much faster, especially when there are lots of flammable items such as newspapers or cardboard."
The Brigade's 999 Control Officers took 16 calls to the blaze.
The Brigade was called at 0211 and the fire was under control by 0320. Fire crews from East Ham, Plaistow, Barking, Poplar and Stratford fire stations were at the scene.
The cause of the fire is under investigation.