Six fire engines and around 40 firefighters tackled a fire on Millet Road in Greenford.
A shed was destroyed by fire. Part of a garage and a small part of a two-storey terraced house was also damaged by fire. An outbuilding from a neighbouring property was destroyed by fire. There have been no reports of injuries.
The Brigade's 999 Control Officers received 12 calls about the fire.
The Brigade was called at 0529 and the fire was under control by 0641. Crews from Southall, Northolt, Ealing, Hillingdon and Feltham fire stations attended the scene.
The cause of the fire is under investigation.