Six fire engines and around 40 firefighters tackled a fire on Dorchester Avenue in Palmers Green.
A two-storey mid-terraced house was destroyed by fire. Two single-storey extensions at adjacent properties were also damaged by fire. There were no reports of any injuries.
The Brigade's 999 Control Officers received 27 calls about the fire.
The Brigade was called at 1525 and the fire was brought under control by 1733. Crews from Tottenham, Hornsey, Finchley, Edmonton and surrounding fire stations attended the scene.
The cause of the fire is under investigation.