Six fire engines and around 40 firefighters tackled a fire at a mixed-use commercial building on Coldharbour Lane in Rainham.
Half of the first floor of the four-storey building was damaged by fire. There were no reports of any injuries.
The Brigade was called at 2222 and the fire was brought under control by 0031. Crews from Wennington, Barking, Dagenham, Hornchurch and Romford fire stations attended the scene.
The cause of the fire is under investigation.