Six fire engines and around 40 firefighters tackled a fire on Hoe Street in Walthamstow.
Part of a ground-floor shop, with homes above, was damaged by fire. There were no reports of any injuries.
The Brigade was called at 2311 and the fire was brought under control by 0101. Crews from Walthamstow, Leyton, Tottenham, Woodford and Leytonstone fire stations attended the scene.
The cause of the fire is under investigation.