Four fire engines and around 25 firefighters tackled a fire at a flat on Gregory Road in Chadwell Heath.
Part of a ground floor flat was damaged by fire. A man was rescued from the flat by firefighters wearing breathing apparatus. He was taken to hospital by London Ambulance Service crews. A woman left the flat before firefighters arrived. She was treated at the scene by ambulance crews.
The Brigade was called at 0358 and the fire was under control by 0519. Crews from Dagenham, Romford and Hainault fire stations attended the scene.
The cause of the fire is under investigation.