Four fire engines and around 25 firefighters tackled a fire at a shop on Lea Bridge Road in Leyton.
Half of the ground floor was damaged by fire. Four people left homes above the building before firefighters arrived. There are no reports of injuries.
Lea Bridge Road was closed to allow crews to deal with the incident. A 25 metre cordon remains in place.
The Brigade's 999 Control Officers received 7 calls about the fire.
The Brigade was called at 0821 and the fire was under control by 0943. Crews from Leyton, Leytonstone, and Walthamstow fire stations were in attendance at the scene.
The cause of the fire is not known at this time.