Three fire engines and around 15 firefighters tackled a fire on a boat at London Bridge Moorings.
A small part of a barge, containing timber and household equipment was damaged by fire. There were no reports of any injuries.
The Brigade was called at 0013 and the fire was under control by 0146. Fire crews from Dockhead, Dowgate and Whitechapel fire stations attended the scene.
The cause of the fire is under investigation.