Four fire engines and around 25 firefighters tackled a fire on Dorset Road in Forest Gate.
A range of single-storey garages were destroyed by fire. There were no reports of any injuries.
The Brigade was called at 1259 and the fire was under control by 1436. Crews from Plaistow, Leytonstone, East Ham and Stratford fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.