Four fire engines and around 25 firefighters tackled a house fire on Crewys Road in Nunhead.
Half of the first floor of a mid-terraced house was damaged by fire. There were no reports of any injuries.
Firefighters used thermal imaging cameras to carry out a thorough search of the building to check for fire spread and identify any remaining hot spots.
A London Fire Brigade spokesperson said: “Firefighters recommend that you have a look at our online Home Fire Safety Checker to make sure there are no hidden hazards in your home.
“The online tool will ask you a series of questions that will help us work out the level of risk in your home, or the home of someone you care for. It only takes a few minutes to get tailored advice to keep yourself and loved ones safe from fire.”
The Brigade was called at 0220 and the fire was under control by 0346. Fire crews from New Cross, Peckham, Old Kent Road and Greenwich fire stations attended the scene.
The cause of the fire is under investigation.