Four fire engines and around 25 firefighters tackled a fire at a derelict maisonette on Maryon Grove in Charlton.
Two maisonettes on the first and second floors of the building were destroyed by fire. There were no reports of any injuries.
The Brigade was called at 2025 and the fire was under control by 2130. Fire crews from Plumstead, Eltham and Greenwich fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.