Four fire engines and around 25 firefighters tackled a fire at a recycling centre on Yabsley Street in Poplar.
Half of a loading bay containing four tonnes of refuse inside a warehouse was damaged by fire. There have been no reports of any injuries.
The Brigade was called at 0937 and the fire was brought under control by 1041. Crews from Millwall, Poplar and East Greenwich fire stations attended the scene.
The fire is being treated as accidental and the cause of the fire has been recorded as undetermined.