Six fire engines and around 40 firefighters tackled a fire at a derelict building on Jubilee Way in Hounslow.
A small part of the first floor of a derelict office building was damaged by the fire. There were no reports of any injuries.
The Brigade was called at 1825 and the fire was under control at 1950. Fire crews from Feltham, Heathrow, Heston, Hayes and Twickenham fire stations attended the scene.
The cause of the fire is under investigation.