Four fire engines and around 25 firefighters tackled a house fire on Hampton Road in Forest Gate.
The first floor of a mid-terraced house was destroyed by fire. One man was taken to hospital by London Ambulance Service crews.
The Brigade was called at 2035 and the fire was under control by 2125. Fire crews from Stratford, Leytonstone, East Ham and Plaistow fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.