Eight fire engines and around 60 firefighters responded to a fire on Marylebone Road, Marylebone.
The fire was in a flat on the seventh floor of a residential block of nine floors. Around a quarter of a four room flat was alight. One resident was taken to hospital by the London Ambulance Service.
Due to the age of the building and lack of a dry rising main, the Brigade deployed a 32m Ladder as a temporary rising main external to the building to aid firefighting.
The Brigade was first called about the incident at 0253 and the fire was under control by 0509. Firefighters from Paddington, Soho, Kensington and surrounding fire stations attended the scene.
The cause of the fire is under investigation.