Six fire engines and around 40 firefighters tackled a fire at a mixed-use building on Woodside Road in Sidcup.
Part of the first floor and the roof of a semi-detached house converted into an office and flats were damaged by fire. Three people left the building before the Brigade arrived. A woman and a child were taken to hospital by London Ambulance Service crews after suffering from smoke inhalation and a man was treated on scene.
Station Commander Stephen Irvine said: "One of the Brigade's new command units was used at the scene for the first time.
"The deployable camera, carried on each command unit, was used to stream imagery back to incident commanders, enhancing situational awareness."
Command units are specially designed vehicles which contain a large working area, computers and communications equipment. They are sent to an incident where three or more fire engines are present, or in some other circumstances where extra command support is required.
The Brigade's new command units are converted single-decker buses and are designed to put digital working at the forefront, allowing information to be passed across the incident ground and increasing situational awareness for incident commanders and those monitoring remotely. It is another step in how the Brigade is transforming to provide a better service to Londoners.
The Brigade was called at 0731 and the fire was under control by 0906. Fire crews from Sidcup, Eltham, Bexley, Bromley, Plumstead and surrounding fire stations attended the scene.
The cause of the fire is under investigation.