Ten fire engines and around 70 firefighters tackled a flat fire on Ilford Hill, Ilford.
Half of a four-roomed flat on the eighth floor of a residential block was damaged by fire. Five adults and two children left the building before the Brigade arrived via an internal staircase, and were taken to hospital by London Ambulance Service crews.
The fire is believed to have been accidental and caused by a candle.
A London Fire Brigade spokesperson said: “Candles, incense sticks and oil burners are one of the most common causes of fire. It’s really important that you never leave a candle unattended and keep them away from anything that can easily catch fire.
“You should also ensure they are in a heat-resistant holder and placed on a stable surface so they won’t be knocked over.
“Firefighters recommend that you have a look at our online Home Fire Safety Checker to make sure there are no hidden hazards in your home."
The Brigade was called at 0150 and the fire was under control by 0300. Fire crews from Ilford, Barking, Dagenham and surrounding fire stations attended the scene.