Four fire engines and around 25 firefighters tackled a shop fire on Tachbrook Street in Pimlico.
Part of a single-storey, end-of-terrace shop was damaged by fire. There were no reports of any injuries.
One of the Brigade's 32-metre turntable ladders was used at the scene as an observation platform and thermal imaging cameras were used to check for any fire spread and remaining hot spots.
The Brigade was called at 0620 and the fire was under control by 0723. Fire crews from Soho, Chelsea and Lambeth fire stations attended the scene.
The cause of the fire is under investigation.