Four fire engines and around 25 firefighters tackled a house fire on Melbourne Road in Walthamstow.
The ground floor of a mid-terraced house was destroyed and part of the first floor was also damaged by fire. There were no reports of any injuries.
The Brigade's 999 Control Officers took 17 calls to the blaze.
The Brigade was called at 1323. Fire crews from Tottenham, Stoke Newington, Woodford and Hornsey fire stations attended the scene.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.