Eight fire engines and around 60 firefighters were called to a warehouse fire on West Gate in Ealing.
Half of a two-storey industrial unit was destroyed in the fire. There were no injuries reported.
The Brigade was called at 0208 and the fire was under control by 0411. Fire crews from Park Royal, Acton, Wembley, Ealing, Chiswick, Willesden and Northolt fire stations attended the scene.
The Brigade's Control Office received eight calls about the fire.
The cause of the fire is under investigation.