Twelve fire engines and around 80 firefighters tackled a fire at a derelict pub on London Road in Mitcham.
Half of the ground, first and second floors of the building were damaged by fire and the roof was destroyed. One person was assessed on scene by London Ambulance Service crews.
Two of the Brigade's 32-metre turntable ladders were used as water towers to tackle the fire from height.
Two gas cylinders were removed from the property as a precaution as some cylinders can explode when exposed to heat.
The Brigade's 999 Control Officers took 34 calls to the blaze.
The Brigade was called at 1929 and the fire was under control by 2218. Fire crews from Norbury, Wimbledon, Tooting and surrounding fire stations attended the scene.
Due to the unsafe structure of the building, the cause of the fire is currently undetermined.