Six fire engines and around 40 firefighters tackled a fire at a shop with flats above on Uxbridge Road in Shepherd's Bush.
Half of a ground floor car workshop was damaged by fire. There are no reports of any injuries.
The Brigade's 999 Control Officers took over ten calls to the blaze. The Brigade was called at 0620 and the fire was under control by 0743. Crews from Hammersmith, Acton, North Kensington and surrounding fire stations attended the scene.
The cause of the fire is under investigation.