Four fire engines and around 25 firefighters tackled a fire at an open air yard on Dock Road in Silvertown.
One van was destroyed by the fire and most of a car and lorry were damaged by the fire. There are currently no reports of any injuries.
The Brigade was called at 1951 and the fire was under control by 2102. Crews from Poplar, Millwall, Shadwell, East Greenwich attended the scene.