Five fire engines and around 30 firefighters tackled a fire at a block of flats on Wheelers Cross in Barking.
Half of a four roomed flat on the eleventh floor was damaged by the fire. There were no reports of any injuries.
One of the Brigade's 64-metre turntable ladders was used at the scene as an observation tower to provide the Incident Commander with an aerial view of the fire.
The Brigade was called at 0024 and the fire was extinguished by 0135. Crews from Barking, East Ham and Plaistow Fire Stations attended the scene.
The cause of the fire is under investigation.