Six fire engines and around 40 firefighters tackled a fire at a storage unit on Roebuck Road in Hainault.
Part of a storage unit was damaged by the fire. A skip was destroyed by the fire. There were no reports of any injuries.
One of the Brigade's 32-metre turntable ladders was used at the scene to help fight the fire from above.
The Brigade was called at 2314 and the fire was under control by 0026. Crews from Hainault, Romford, Ilford and surrounding fire stations attended the scene.
The cause of the fire has been recorded as undetermined.