Six fire engines and around 40 firefighters tackled a fire at a shop with flats above on Ardleigh Green Road in Hornchurch.
A cash machine was destroyed and a half of a secure room on the ground floor and a first-floor flat were damaged by fire. There were no reports of any injuries.
The Brigade's Control Officers received the first call at 0202 and mobilised crews from Hornchurch, Harold Hill, Romford, Dagenham and surrounding fire stations to the scene. The fire was under control by 0307.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.