Four fire engines and around 25 firefighters tackled a house fire on Thanet Road in Erith.
Half of the ground floor of the two-storey house was damaged by fire. There are no reports of any injuries.
The Brigade was called at 0518 and the fire was under control by 0625. Crews from Erith, Bexley, Sidcup and Plumstead fire stations attended the scene.
The cause of the fire is under investigation.